2,4-Hexadiyne-1,6-diol
- CasNo:3031-68-3
Product Description
Manufacturer supply top purity 2,4-Hexadiyne-1,6-diol 3031-68-3 with GMP standards
- Molecular Formula: C6H6O2
- Molecular Weight: 110.112
- Vapor Pressure: 0.0002mmHg at 25°C
- Melting Point: 109-112 °C
- Refractive Index: 1.561
- Boiling Point: 292.1 °C at 760 mmHg
- PKA: 12.26±0.10(Predicted)
- Flash Point: 151 °C
- PSA： 40.46000
- Density: 1.234 g/cm3
- LogP: -1.02220
2,4-Hexadiyne-1,6-diol(Cas 3031-68-3) Usage
|
General Description |
2,4-Hexadiyne-1,6-diol can be prepared from propargyl alcohol. 2,4-Hexadiyne-1,6-diol readily undergoes polymerization when heated under vacuum or inert gas atmosphere. |
InChI:InChI=1/C6H6O2/c7-5-3-1-2-4-6-8/h7-8H,5-6H2
3031-68-3 Relevant articles
Synthesis of 1,3-diynes using palladium-copper catalyses
Wityak,Chan
, p. 977 - 979 (1991)
-
Features of the mechanism of oxidative dehydrodimerization of propynol
Fedenok, Lidiya G.,Shvartsberg, Mark S.
, p. 3776 - 3778 (2011)
Analysis of kinetic regularities for the...
Mechanistic investigation and further optimization of the aqueous Glaser-Hay bioconjugation
Travis, Christopher R.,Mazur, Lauren E.,Peairs, Emily M.,Gaunt, Gillian H.,Young, Douglas D.
, p. 3396 - 3402 (2019)
The Glaser-Hay bioconjugation has recent...
First total synthesis of acetylenic alcohol 15-methyltricosa-2,4-diyne-1, 6-diol (strongylodiol-G) derived from marine sponge
Gupta, Neeraj,Shallu,Kad, Goverdhan Lal,Singh, Jasvinder
, p. 424 - 430 (2014)
The first total and efficient synthesis ...
Glaser coupling reaction in supercritical carbon dioxide
Li, Jinheng,Jiang, Huanfeng
, p. 2369 - 2370 (1999)
It is demonstrated for the first time th...
-
Shergina,S.I. et al.
, (1973)
-
Noncatalytic, solvent-free thermal formation of cyclic trimers using 1,6-bis(acyloxymethyl)hexa-2,4-diyne derivatives
Taniguchi, Shin-Ichi,Yokoi, Toshihiro,Izuoka, Akira,Matsushita, Michio M.,Sugawara, Tadashi
, p. 2671 - 2675 (2004)
The thermal reactivity of diacetylenes i...
Catalytically active self-assembled silica-based nanostructures containing supported nanoparticles
Gonzalez-Arellano, Camino,Balu, Alina Mariana,Luque, Rafael,MacQuarrie, Duncan J.
, p. 1995 - 2002 (2010)
Self-assembled tubular silica-based nano...
Glaser oxidative coupling in ionic liquids: An improved synthesis of conjugated 1,3-diynes
Yadav,Reddy,Reddy, K. Bhaskar,Gayathri, K. Uma,Prasad
, p. 6493 - 6496 (2003)
Terminal alkynes undergo oxidative-coupl...
Leaf-like CuO nanosheets on rGO as an efficient heterogeneous catalyst for Csp-Csp homocoupling of terminal alkynes
Gao, Lingfeng,Wang, Bin,Zheng, Gengxiu
, (2020/12/21)
In this work, the economic and well-defi...
In the optically-multiplexed-
-
Paragraph 0216; 0217, (2020/12/30)
A method for optical super-multiplexing ...
Synthesis of ene-yne-enes by nickel-catalyzed double SN2′ substitution of 1,6-dichlorohexa-2,4-diyne
Wang, Gongbao,Lindeboom, Erik-Jan,Van Heerewaarden, Chris,Minnaard, Adriaan J.
, p. 2347 - 2355 (2017/07/22)
1,6-Dichlorohexa-2,4-diyne undergoes nic...
3031-68-3 Process route
-
-
107-19-7
propargyl alcohol
-
-
536-74-3
phenylacetylene
-
-
30353-46-9
5-phenyl-2,4-pentadiyn-1-ol
-
-
886-66-8
1,4-diphenyl-1,3-butadiyne
-
-
3031-68-3
Hexa-2,4-diyne-1,6-diol
| Conditions | Yield |
|---|---|
|
With
copper acetylacetonate; iron(III)-acetylacetonate; potassium carbonate;
In
N,N-dimethyl-formamide;
at 50 ℃;
for 12h;
|
45%
70% 10% |
|
With
oxygen; 1,8-diazabicyclo[5.4.0]undec-7-ene; copper dichloride;
In
tetrahydrofuran;
at 20 ℃;
for 24h;
Air atmosphere;
|
70%
17% 18% |
-
-
107-19-7
propargyl alcohol
-
-
3031-68-3
Hexa-2,4-diyne-1,6-diol
| Conditions | Yield |
|---|---|
|
With
copper(l) iodide; triethylamine; triphenylphosphine;
bis-triphenylphosphine-palladium(II) chloride;
In
acetonitrile;
at 25 ℃;
for 24h;
|
98%
|
|
With
N,N,N,N,-tetramethylethylenediamine; oxygen; copper(l) chloride;
In
acetone;
at 20 ℃;
Inert atmosphere;
|
95%
|
|
With
copper(l) iodide; nickel(II) chloride hexahydrate; N,N,N,N,-tetramethylethylenediamine; oxygen; triethylamine;
In
tetrahydrofuran;
for 24h;
|
95%
|
|
With
air; diethylamine; copper(l) chloride;
at 20 ℃;
for 3h;
|
94%
|
|
With
copper(l) iodide; ethyl bromoacetate; N-ethyl-N,N-diisopropylamine;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran;
at 20 ℃;
|
94%
|
|
With
copper(l) iodide; nickel(II) chloride hexahydrate; N,N,N,N,-tetramethylethylenediamine; oxygen;
In
tetrahydrofuran;
at 20 ℃;
|
92%
|
|
With
copper(l) iodide; nickel(II) chloride hexahydrate; N,N,N,N,-tetramethylethylenediamine;
In
tetrahydrofuran;
at 20 ℃;
for 1h;
Inert atmosphere;
Darkness;
|
92%
|
|
With
N,N,N,N,-tetramethylethylenediamine; oxygen; copper(l) chloride;
In
acetone;
for 20h;
Ambient temperature;
|
89%
|
|
With
N,N,N,N,-tetramethylethylenediamine; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate; copper(l) chloride;
at 20 ℃;
for 7.5h;
|
89%
|
|
With
copper diacetate; sodium acetate; PEG 6000;
at 120 ℃;
for 18h;
|
86%
|
|
With
tetrakis(triphenylphosphine) palladium(0); silver(l) oxide;
In
tetrahydrofuran;
at 60 ℃;
for 18h;
Inert atmosphere;
|
85%
|
|
With
sodium acetate; silica gel; copper dichloride;
for 6h;
|
84%
|
|
With
copper(l) iodide; sodium acetate;
In
N,N-dimethyl-formamide;
at 90 ℃;
for 5h;
|
78%
|
|
With
N,N,N,N,-tetramethylethylenediamine; copper(l) chloride;
In
acetone;
at 23 - 31 ℃;
|
73%
|
|
With
4,4’‐bis(trimethylammoniummethyl)‐2,2’‐bipyridine; copper(ll) sulfate pentahydrate; iodine; potassium acetate;
In
water;
at 120 ℃;
for 24h;
|
72%
|
|
With
sodium acetate; copper dichloride;
In
methanol; carbon dioxide;
at 40 ℃;
for 4h;
under 105008 Torr;
|
71%
|
|
With
carbon dioxide; sodium acetate; copper dichloride;
In
methanol;
at 40 ℃;
for 4h;
under 105008 Torr;
|
71%
|
|
With
pyridine; oxygen; copper(l) chloride;
for 48h;
|
70%
|
|
With
copper(l) iodide; iodine; sodium carbonate;
In
N,N-dimethyl-formamide;
at 80 ℃;
for 5h;
|
70%
|
|
With
piperidine; copper(II) acetate monohydrate;
In
dichloromethane;
at 25 ℃;
for 3h;
air;
|
69%
|
|
With
4,4'-di-tert-butylbiphenyl; lithium; copper dichloride;
In
tetrahydrofuran;
at 66 ℃;
for 16h;
Inert atmosphere;
|
68%
|
|
With
oxygen; 1,8-diazabicyclo[5.4.0]undec-7-ene; copper dichloride;
In
tetrahydrofuran;
at 20 ℃;
for 24h;
Air atmosphere;
|
68%
|
|
With
ammonium chloride; copper(l) chloride;
In
water;
at 55 - 60 ℃;
for 4h;
|
65%
|
|
With
copper(I) chloride; oxygen;
In
pyridine; methanol;
for 1h;
|
60%
|
|
copper diacetate;
In
pyridine; methanol;
|
56%
|
|
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine;
In
N,N-dimethyl-formamide;
for 6h;
Ambient temperature;
|
54.5%
|
|
With
triethylamine; copper dichloride;
at 60 ℃;
for 6h;
Neat (no solvent);
Air atmosphere;
|
45%
|
|
With
oxygen; sodium hydroxide;
In
ethanol;
at 80 ℃;
for 12h;
Green chemistry;
|
43%
|
|
With
basolite C300; potassium carbonate;
In
1,4-dioxane;
at 85 ℃;
for 24h;
|
35%
|
|
With
ammonium chloride; copper(l) chloride;
In
water;
|
23%
|
|
With
water; oxygen; ammonium chloride; copper(l) chloride;
|
|
|
With
copper chloride; potassium hexacyanoferrate(III);
|
|
|
|
|
|
With
oxygen; copper;
|
|
|
With
copper(l) iodide; N,N,N,N,-tetramethylethylenediamine; oxygen;
In
1,2-dimethoxyethane;
at 55 ℃;
|
|
|
With
oxygen;
(TBA)4[γ-H2SiW10O36Cu2(μ-1,1-N3)2];
In
benzonitrile;
at 99.84 ℃;
for 18h;
under 760.051 Torr;
|
85 % Chromat.
|
|
With
oxygen;
In
benzonitrile;
at 99.84 ℃;
for 18h;
under 760.051 Torr;
|
85 %Chromat.
|
|
With
pyridine; oxygen;
copper(l) chloride;
In
methanol;
for 48h;
|
|
|
With
oxygen;
In
benzonitrile;
at 100 ℃;
for 18h;
under 760.051 Torr;
|
85 %Chromat.
|
|
With
1,4-diaza-bicyclo[2.2.2]octane;
at 140 - 170 ℃;
for 0.75h;
Microwave irradiation;
|
|
|
With
piperidine; pyridine; tetraethylammonium acetate; oxygen; acetic acid; copper(l) chloride;
at 40 ℃;
pH-value;
Concentration;
Kinetics;
|
|
|
With
oxygen;
In
dimethyl sulfoxide;
at 50 ℃;
for 12h;
under 760.051 Torr;
|
46 %Spectr.
|
|
With
copper(l) iodide; nickel(II) chloride hexahydrate; N,N,N,N,-tetramethylethylenediamine;
In
tetrahydrofuran;
|
|
|
propargyl alcohol;
With
N,N,N,N,-tetramethylethylenediamine; copper(I) thiocyanate; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
acetonitrile;
at 25 - 30 ℃;
With
4-nitrobenzenediazonium tetrafluoroborate;
In
acetonitrile;
at 25 - 30 ℃;
|
58 mg
|
|
With
morpholine;
In
neat (no solvent);
at 60 ℃;
for 15h;
Green chemistry;
|
92 %Chromat.
|
|
With
copper(l) iodide; nickel(II) chloride hexahydrate; N,N,N,N,-tetramethylethylenediamine;
In
tetrahydrofuran;
|
|
|
With
copper(l) iodide; N,N,N,N,-tetramethylethylenediamine;
In
water-d2;
at 80 ℃;
for 12h;
Sealed tube;
|
3031-68-3 Upstream products
-
50-00-0
formaldehyd
-
460-12-8
Butadiyne
-
107-19-7
propargyl alcohol
-
33324-62-8
1,6-bis-(1-butoxy-ethoxy)-hexa-2,4-diyne
3031-68-3 Downstream products
-
32527-15-4
1,6-bis(p-toluenesulfonyloxy)-2,4-hexadiyne
-
109511-56-0
5,5'-bis-hydroxymethyl-1,1'-diphenyl-1H ,1'H -[4,4']bi[1,2,3]triazolyl
-
629-11-8
1,6-hexanediol
-
107550-83-4
(2E,4E)-hexa-2,4-diene-1,6-diol